Paul-Flechsig-Institut für Hirnforschung

Teil der Einrichtung (oder mit ihr assoziiert)

  • Molekulare und zelluläre Mechanismen der Neurodegeneration
  • Molekulare Bildgebung des ZNS
  • Pathophysiologie der Neuroglia
  • Dynamik der Hirnfunktion

Veröffentlichungen in 2015

  • Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P: High membrane protein oxidation in the human cerebral cortex. In: Redox Biol 2015; 4: 200-207 [IF 0]
  • Eggers SD, Horn AK, Roeber S, Härtig W, Nair G, Reich DS, Leigh RJ: Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets. In: PLoS One 2015; 10(7): e0132075 [IF 3,234]
  • Rietkötter E, Bleckmann A, Bayerlova M, Menck K, Chuang HN, Wenske B, Schwartz H, Erez N, Binder C, Hanisch UK, Pukrop T: Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia. In: Oncotarget 2015; 6(17): 15482-15493 [IF 6,359]
  • Berk BA, Vogler S, Pannicke T, Kuhrt H, Garcia TB, Wiedemann P, Reichenbach A, Seeger J, Bringmann A: Brain-derived neurotrophic factor inhibits osmotic swelling of rat retinal glial (Müller) and bipolar cells by activation of basic fibroblast growth factor signaling. In: Neuroscience 2015; 295: 175-186 [IF 3,357]
  • Michalski D, Härtig W, Krueger M, Hobohm C, Käs JA, Fuhs T: A novel approach for mechanical tissue characterization indicates decreased elastic strength in brain areas affected by experimental thromboembolic stroke. In: Neuroreport 2015; 26(10): 583-587 [IF 1,52]
  • Jensen MM, Arvaniti M, Mikkelsen JD, Michalski D, Pinborg LH, Härtig W, Thomsen MS: Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimers disease. In: Neurobiol Aging 2015; 36(4): 1629-1638 [IF 5,013]
  • Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M: Cell type- and brain region-resolved mouse brain proteome. In: Nat Neurosci 2015; 18(12): 1819-1831 [IF 16,095]
  • Hollborn M, Vogler S, Reichenbach A, Wiedemann P, Bringmann A, Kohen L: Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. In: Mol Vis 2015; 21: 360-377 [IF 1,986]
  • Brosig A, Kuhrt H, Wiedemann P, Kohen L, Bringmann A, Hollborn M: Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. In: Mol Vis 2015; 21: 1000-1016 [IF 1,986]
  • Schmidt F, Boltze J, Jäger C, Hofmann S, Willems N, Seeger J, Härtig W, Stolzing A: Detection and Quantification of ß-Amyloid, Pyroglutamyl Aß, and Tau in Aged Canines. In: J Neuropathol Exp Neurol 2015; 74(9): 912-923 [IF 3,797]
  • Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, Hanisch UK, Triebel J, Bollheimer LC, Sieber C, Nau R: Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. In: J Neuroinflammation 2015; 12: 208 [IF 5,408]
  • Wagner L, Wolf R, Zeitschel U, Rossner S, Petersén Ã…, Leavitt BR, Kästner F, Rothermundt M, Gärtner UT, Gündel D, Schlenzig D, Frerker N, Schade J, Manhart S, Rahfeld JU, Demuth HU, von Hörsten S: Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery. In: J Neurochem 2015; 135(5): 1019-1037 [IF 4,281]
  • Pfister S, Weber T, Härtig W, Schwerdel C, Elsaesser R, Knuesel I, Fritschy JM: Novel role of cystic fibrosis transmembrane conductance regulator in maintaining adult mouse olfactory neuronal homeostasis. In: J Comp Neurol 2015; 523(3): 406-430 [IF 3,225]
  • Mitkovski M, Dahm L, Heinrich R, Monnheimer M, Gerhart S, Stegmüller J, Hanisch UK, Nave KA, Ehrenreich H: Erythropoietin dampens injury-induced microglial motility. In: J Cereb Blood Flow Metab 2015; 35(8): 1233-1236 [IF 5,407]
  • Ebbers L, Satheesh SV, Janz K, Rüttiger L, Blosa M, Hofmann F, Morawski M, Griesemer D, Knipper M, Friauf E, Nothwang HG: L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei. In: J Biol Chem 2015; 290(39): 23692-23710 [IF 4,573]
  • Bielarczyk H, Jankowska-Kulawy A, Höfling C, Ronowska A, Gul-Hinc S, Rossner S, Schliebs R, Pawelczyk T, Szutowicz A: AßPP-Transgenic 2576 Mice Mimic Cell Type-Specific Aspects of Acetyl-CoA-Linked Metabolic Deficits in Alzheimers Disease. In: J Alzheimers Dis 2015; 48(4): 1083-1094 [IF 4,151]
  • Immig K, Gericke M, Menzel F, Merz F, Krueger M, Schiefenhovel F, Losche A, Jager K, Hanisch UK, Biber K, Bechmann I: CD11c-positive cells from brain, spleen, lung, and liver exhibit site-specific immune phenotypes and plastically adapt to new environments. In: Glia 2015; 63(4): 611-625 [IF 6,031]
  • Wunderlich KA, Tanimoto N, Grosche A, Zrenner E, Pekny M, Reichenbach A, Seeliger MW, Pannicke T, Perez MT: Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin. In: FASEB J 2015; 29(12): 4815-4828 [IF 5,043]
  • Eschke M, Piehler D, Schulze B, Richter T, Grahnert A, Protschka M, Müller U, Köhler G, Höfling C, Rossner S, Alber G: A novel experimental model of Cryptococcus neoformans-related immune reconstitution inflammatory syndrome (IRIS) provides insights into pathogenesis. In: Eur J Immunol 2015; 45(12): 3339-3350 [IF 4,034]
  • Leovsky C, Fabian C, Naaldijk Y, Jäger C, Jang HJ, Böhme J, Rudolph L, Stolzing A: Biodistribution of in vitro-derived microglia applied intranasally and intravenously to mice: effects of aging. In: Cytotherapy 2015; 17(11): 1617-1626 [IF 3,293]
  • Schaafsma W, Zhang X, van Zomeren KC, Jacobs S, Georgieva PB, Wolf SA, Kettenmann H, Janova H, Saiepour N, Hanisch UK, Meerlo P, van den Elsen PJ, Brouwer N, Boddeke HW, Eggen BJ: Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing. In: Brain Behav Immun 2015; 48: 205-221 [IF 5,889]
  • Mahmudi O, Sennblad B, Arvestad L, Nowick K, Lagergren J: Gene-pseudogene evolution: a probabilistic approach. In: BMC Genomics 2015; 16(Suppl10): S12 [IF 3,986]
  • Eggers SD, Horn AK, Roeber S, Härtig W, Nair G, Reich DS, John Leigh R: Saccadic palsy following cardiac surgery: a review and new hypothesis. In: Ann N Y Acad Sci 2015; 1343(1): 113-119 [IF 4,383]
  • Schuldt C, Karl A, Körber N, Koch C, Liu Q, Fritsch AW, Reichenbach A, Wiedemann P, Käs JA, Francke M, Iseli HP: Dose-dependent collagen cross-linking of rabbit scleral tissue by blue light and riboflavin treatment probed by dynamic shear rheology. In: Acta Ophthalmol 2015; 93(5): e328-336 [IF 2,844]
  • Laubichler MD, Stadler PF, Prohaska SJ, Nowick K: The relativity of biological function. In: Theory Biosci 2015; 134(3-4): 143-147 [IF 1,226]
  • Syrbe S, Merkenschlager A, Bernhard MK, Grosche J, Liebert UG, Hirsch W, Härtig W: Opsoclonus-myoclonus syndrome after adenovirus infection. In: Springerplus 2015; 4: 636 [IF 0]
  • Morawski M, Reinert T, Meyer-Klaucke W, Wagner FE, Tröger W, Reinert A, Jäger C, Brückner G, Arendt T: Ion exchanger in the brain: Quantitative analysis of perineuronally fixed anionic binding sites suggests diffusion barriers with ion sorting properties. In: Sci Rep 2015; 5: 16471 [IF 5,578]
  • Herrmann L, Wiegmann C, Arsalan-Werner A, Hilbrich I, Jäger C, Flach K, Suttkus A, Lachmann I, Arendt T, Holzer M: Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. In: PLoS One 2015; 10(3): 1-23 [IF 3,234]
  • Muche A, Bürger S, Arendt T, Schliebs R: Hypoxic stress, brain vascular system, and ?-amyloid: a primary cell culture study. In: Nutr Neurosci 2015; 18(1): 1-11 [IF 2,274]
  • Bajic V, Spremo-Potparevic B, Zivkovic L, Isenovic ER, Arendt T: Cohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instability. In: Neurosci Biobehav Rev 2015; 55: 365-374 [IF 8,802]
  • Voigt J, Grosche A, Vogler S, Pannicke T, Hollborn M, Kohen L, Wiedemann P, Reichenbach A, Bringmann A: Nonvesicular release of ATP from rat retinal glial (Müller) cells is differentially mediated in response to osmotic stress and glutamate. In: Neurochem Res 2015; 40(4): 651-660 [IF 2,593]
  • Ueberham E, Glöckner P, Göhler C, Straub BK, Teupser D, Schönig K, Braeuning A, Höhn AK, Jerchow B, Birchmeier W, Gaunitz F, Arendt T, Sansom O, Gebhardt R, Ueberham U: Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors. In: Mol Cancer Res 2015; 13(2): 239-249 [IF 4,38]
  • Blosa M, Sonntag M, Jäger C, Weigel S, Seeger J, Frischknecht R, Seidenbecher CI, Matthews RT, Arendt T, Rübsamen R, Morawski M: The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held. In: J Physiol 2015; 593(19): 4341-4360 [IF 5,037]
  • Krueger M, Bechmann I, Immig K, Reichenbach A, Härtig W, Michalski D: Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia. In: J Cereb Blood Flow Metab 2015; 35(2): 292-303 [IF 5,407]
  • Arendt T, Stieler J, Holzer M: Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimers disease pathology. In: J Neural Transm 2015; 122(4): 531-539 [IF 2,402]
  • Sonntag M, Blosa M, Schmidt S, Rübsamen R, Morawski M: Perineuronal nets in the auditory system. In: Hear Res 2015; 329: 21-32 [IF 2,968]
  • Muche A, Bigl M, Arendt T, Schliebs R: Expression of vascular endothelial growth factor (VEGF) mRNA, VEGF receptor 2 (Flk-1) mRNA, and of VEGF co-receptor neuropilin (Nrp)-1 mRNA in brain tissue of aging Tg2576 mice by in situ hybridization. In: Int J Dev Neurosci 2015; 43: 25-34 [IF 2,58]
  • Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Gotz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK: Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism. In: Glia 2015; 63(6): 1083-1099 [IF 6,031]
  • Reichel JM, Nissel S, Rogel-Salazar G, Mederer A, Käfer K, Bedenk BT, Martens H, Anders R, Grosche J, Michalski D, Härtig W, Wotjak CT: Distinct behavioral consequences of short-term and prolonged GABAergic depletion in prefrontal cortex and dorsal hippocampus. In: Front Behav Neurosci 2015; 8: 452 [IF 3,27]
  • Iseli HP, Körber N, Karl A, Koch C, Schuldt C, Penk A, Liu Q, Huster D, Käs J, Reichenbach A, Wiedemann P, Francke M: Damage threshold in adult rabbit eyes after scleral cross-linking by riboflavin/blue light application. In: Exp Eye Res 2015; 139: 37-47 [IF 2,709]
  • Kara F, Höfling C, Rossner S, Schliebs R, Van der Linden A, Groot HJ, Alia A: In Vivo Longitudinal Monitoring of Changes in the Corpus Callosum Integrity During Disease Progression in a Mouse Model of Alzheimers Disease. In: Curr Alzheimer Res 2015; 12(10): 941-950 [IF 3,889]
  • Arendt T, Brückner MK, Morawski M, Jäger C, Gertz HJ: Early neurone loss in Alzheimers disease: cortical or subcortical? In: Acta Neuropathol Commun 2015; 3(1): 1-11 [IF 0]
  • Waniek A, Hartlage-Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth HU, Rossner S: Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes. In: Biochim Biophys Acta 2015; 1852(1): 146-155 [IF 4,882]
  • Arendt T, Brückner MK, Lösche A: Regional mosaic genomic heterogeneity in the elderly and in Alzheimers disease as a correlate of neuronal vulnerability. In: Acta Neuropathol 2015; 130(4): 501-510 [IF 10,762]
  • Hartlage-Rübsamen M, Waniek A, Meissner J, Morawski M, Schilling S, Jager C, Kleinschmidt M, Cynis H, Kehlen A, Arendt T, Demuth HU, Roßner S: Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimers disease. In: Acta Neuropathol 2015; 129(4): 565-583 [IF 10,762]

letzte Änderung: 26.07.2012


Paul-Flechsig-Institut für Hirnforschung
Arendt, Thomas (Prof. Dr.)
Liebigstraße 19, Haus C
04103 Leipzig
Telefon: +49 341 97-25 720
Fax: +49 341 97-25 729


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